THE AXON HILLOCK AND THE INITIAL SEGMENT
نویسندگان
چکیده
منابع مشابه
The Axon Hillock and the Initial Segment
Axon hillocks and initial segments have been recognized and studied in electron micrographs of a wide variety of neurons. In all multipolar neurons the fine structure of the initial segment has the same pattern, whether or not the axon is ensheathed in myelin. The internal structure of the initial segment is characterized by three special features: (a) a dense layer of finely granular material ...
متن کاملThe Small Pyramidal Neuron of the Rat Cerebral Cortex the Axon Hillock and Initial Segment
The axon of the pyramidal neuron in the cerebral cortex arises either directly from the peri-karyon or as a branch from a basal dendrite. When it arises from the perikaryon, an axon hillock is present. The hillock is a region in which there is a transition between the cytologi-cal features of the perikaryon and those of the initial segment of the axon. Thus, in the hillock there is a diminution...
متن کاملBuilding and maintaining the axon initial segment.
The axon initial segment is a unique neuronal subregion involved in the initiation of action potentials and in the control of axonal identity. Recent work has helped our understanding of how this specialised structure develops, not least in identifying possible mechanisms leading to the localisation of the AIS's master organiser protein, ankyrin-G. The most exciting current work, however, focus...
متن کاملSignal Processing in the Axon Initial Segment
The axon initial segment (AIS) is a specialized membrane region in the axon of neurons where action potentials are initiated. Crucial to the function of the AIS is the presence of specific voltage-gated channels clustered at high densities, giving the AIS unique electrical properties. Here we review recent data on the physiology of the AIS. These data indicate that the role of the AIS is far ri...
متن کاملStructural and Functional Plasticity at the Axon Initial Segment
The axon initial segment (AIS) is positioned between the axonal and somato-dendritic compartments and plays a pivotal role in triggering action potentials (APs) and determining neuronal output. It is now widely accepted that structural properties of the AIS, such as length and/or location relative to the soma, change in an activity-dependent manner. This structural plasticity of the AIS is know...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1968
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.38.1.193